| 16. Round | 10/01/2022 | Derby County U23 | - | Liverpool FC U23 | 0:1 | ||||
| 17. Round | 15/01/2022 | Liverpool FC U23 | - | Everton FC U23 | 1:1 | ||||
| 18. Round | 24/01/2022 | Crystal Palace U23 | - | Liverpool FC U23 | 0:2 | ||||
| 19. Round | 07/02/2022 | Leeds United U23 | - | Liverpool FC U23 | 3:0 |  |
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| 20. Round | 20/02/2022 | Liverpool FC U23 | - | Blackburn Rovers U23 | 1:1 | ||||
| 21. Round | 25/02/2022 | Arsenal FC U23 | - | Liverpool FC U23 | 1:4 | ||||
| 22. Round | 12/03/2022 | Liverpool FC U23 | - | Tottenham Hotspur U23 | 7:1 |  |
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| 23. Round | 20/03/2022 | Manchester City U23 | - | Liverpool FC U23 | 0:0 | ||||
| 24. Round | 02/04/2022 | Liverpool FC U23 | - | Chelsea FC U23 | 2:2 | ||||
| 15. Round | 17/04/2022 | Liverpool FC U23 | - | West Ham United U23 | 3:0 | ||||
| 25. Round | 25/04/2022 | Leicester City U23 | - | Liverpool FC U23 | 0:4 | |
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| 26. Round | 01/05/2022 | Liverpool FC U23 | - | Manchester United U23 | 3:1 |
England