| 1. Round | 05/09/2021 | Sestao River | - | CD Laredo | 2:0 |  |
|||
| 2. Round | 12/09/2021 | Real Sociedad C | - | Sestao River | 1:0 | ||||
| 3. Round | 19/09/2021 | Sestao River | - | AD San Juan | 2:1 | ||||
| 4. Round | 26/09/2021 | Arenas de Getxo | - | Sestao River | 1:1 | ||||
| 7. Round | 17/10/2021 | Sestao River | - | CF Ardoi | 4:0 | ||||
| 8. Round | 23/10/2021 | Peña Sport FC | - | Sestao River | 0:0 | ||||
| 9. Round | 31/10/2021 | Sestao River | - | CD Cayón | 3:0 | ||||
| 10. Round | 06/11/2021 | Rayo Cantabria | - | Sestao River | 1:2 | |
|||
| 11. Round | 14/11/2021 | Náxara CD | - | Sestao River | 2:1 | |
|||
| 12. Round | 20/11/2021 | Sestao River | - | CA Osasuna B | 1:2 | ||||
| 13. Round | 27/11/2021 | SD Gernika | - | Sestao River | 0:2 | |
|||
| 14. Round | 05/12/2021 | Sestao River | - | UD Logroñés Promesas | 2:1 | ||||
| 17. Round | 09/01/2022 | CD Tropezón | - | Sestao River | 1:0 | ||||
| 24. Round | 05/03/2022 | CF Ardoi | - | Sestao River | 0:2 | ||||
| 25. Round | 13/03/2022 | Sestao River | - | Peña Sport FC | 1:0 | ||||
| 27. Round | 27/03/2022 | Sestao River | - | Rayo Cantabria | 0:0 | ||||
| 28. Round | 03/04/2022 | Sestao River | - | Náxara CD | 2:0 | ||||
| 30. Round | 16/04/2022 | Sestao River | - | SD Gernika | 3:2 | ||||
| 34. Round | 15/05/2022 | Sestao River | - | CD Tropezón | 4:2 |
Spain