| 1. Round | 11/02/2022 | Unión de Santa Fe II | - | River Plate II | 0:0 | ||||
| 2. Round | 15/02/2022 | Talleres de Córdoba II | - | Unión de Santa Fe II | 5:0 | ||||
| 3. Round | 19/02/2022 | Unión de Santa Fe II | - | Atlético Tucumán II | 1:0 | ||||
| 8. Round | 01/04/2022 | Patronato de Paraná II | - | Unión de Santa Fe II | 1:1 | ||||
| 9. Round | 08/04/2022 | Unión de Santa Fe II | - | Newell's Old Boys II | 1:1 | ||||
| 10. Round | 15/04/2022 | Racing Club II | - | Unión de Santa Fe II | 2:0 | ||||
| 11. Round | 20/04/2022 | Unión de Santa Fe II | - | San Lorenzo II | 1:4 |
Argentina