| 1. Round | 25/06/2022 | Santos Laguna [] | - | Deportivo Guadalajara [] | 0:1 | ||||
| 2. Round | 03/07/2022 | Deportivo Guadalajara [] | - | Atlas Guadalajara [] | 1:3 | ||||
| 3. Round | 09/07/2022 | UANL Tigres [] | - | Deportivo Guadalajara [] | 0:1 | ||||
| 4. Round | 16/07/2022 | Deportivo Guadalajara [] | - | Club León [] | 2:1 | ||||
| 6. Round | 31/07/2022 | Club Tijuana [] | - | Deportivo Guadalajara [] | 3:1 | ||||
| 7. Round | 06/08/2022 | Deportivo Guadalajara [] | - | CF Monterrey [] | 0:1 | ||||
| 9. Round | 20/08/2022 | Deportivo Guadalajara [] | - | Mazatlán FC [] | 4:1 | ||||
| 10. Round | 28/08/2022 | Deportivo Guadalajara [] | - | Santos Laguna [] | 1:1 | ||||
| 11. Round | 03/09/2022 | Mazatlán FC [] | - | Deportivo Guadalajara [] | 2:8 | ||||
| 12. Round | 11/09/2022 | Deportivo Guadalajara [] | - | Atlético San Luis [] | 3:1 | ||||
| 13. Round | 16/09/2022 | CF Monterrey [] | - | Deportivo Guadalajara [] | 0:2 | ||||
| 17. Round | 15/10/2022 | Deportivo Guadalajara [] | - | UANL Tigres [] | 6:1 | ||||
| 18. Round | 22/10/2022 | Atlas Guadalajara [] | - | Deportivo Guadalajara [] | 1:0 |
Mexico