| 1. Round | 09/01/2022 | CF Monterrey | - | Gallos Blancos | 0:0 | ||||
| 2. Round | 15/01/2022 | Gallos Blancos | - | Pumas UNAM | 1:3 | ||||
| 3. Round | 22/01/2022 | Deportivo Guadalajara | - | Gallos Blancos | 1:1 |  |
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| 4. Round | 06/02/2022 | Gallos Blancos | - | Puebla FC | 0:2 | ||||
| 5. Round | 15/02/2022 | CF Pachuca | - | Gallos Blancos | 2:2 | ||||
| 6. Round | 19/02/2022 | Gallos Blancos | - | Mazatlán FC | 2:0 | ||||
| 8. Round | 02/03/2022 | CF América | - | Gallos Blancos | 1:1 | ||||
| 9. Round | 05/03/2022 | Gallos Blancos | - | Atlas Guadalajara | 0:3 dec. | ||||
| 10. Round | 12/03/2022 | Club Necaxa | - | Gallos Blancos | 1:0 | ||||
| 11. Round | 18/03/2022 | Gallos Blancos | - | Atlético San Luis | 2:1 | |
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| 12. Round | 03/04/2022 | Club León | - | Gallos Blancos | 1:1 | ||||
| 13. Round | 11/04/2022 | Gallos Blancos | - | UANL Tigres | 0:1 | ||||
| 14. Round | 17/04/2022 | Santos Laguna | - | Gallos Blancos | 1:1 | |
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| 15. Round | 22/04/2022 | Gallos Blancos | - | Cruz Azul | 0:1 | ||||
| 16. Round | 25/04/2022 | Club Tijuana | - | Gallos Blancos | 2:2 | ||||
| 17. Round | 30/04/2022 | Gallos Blancos | - | FC Juárez | 4:0 | |
Argentina