| 1. Round | 22/08/2021 | Olympique Marseille [Youth] | - | Nîmes Olympique [Youth] | 7:3 |  |
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| 2. Round | 29/08/2021 | Nîmes Olympique [Youth] | - | AS Cannes [Youth] | 0:2 | ||||
| 3. Round | 05/09/2021 | OGC Nice [Youth] | - | Nîmes Olympique [Youth] | 1:1 | ||||
| 4. Round | 12/09/2021 | Nîmes Olympique [Youth] | - | Toulouse FC [Youth] | 0:1 | ||||
| 5. Round | 19/09/2021 | FC Istres [Youth] | - | Nîmes Olympique [Youth] | 5:1 | |
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| 6. Round | 26/09/2021 | Nîmes Olympique [Youth] | - | Pieve di Lota [Youth] | 4:1 | |
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| 7. Round | 03/10/2021 | AS Monaco [Youth] | - | Nîmes Olympique [Youth] | 4:2 | ||||
| 8. Round | 10/10/2021 | Nîmes Olympique [Youth] | - | US Colomiers [Youth] | 1:0 | ||||
| 10. Round | 23/10/2021 | AS Saint-Étienne [Youth] | - | Nîmes Olympique [Youth] | 2:0 | ||||
| 11. Round | 14/11/2021 | Nîmes Olympique [Youth] | - | Montpellier HSC [Youth] | 1:3 | ||||
| 13. Round | 28/11/2021 | Nîmes Olympique [Youth] | - | SC Toulon [Youth] | 0:2 | ||||
| 14. Round | 05/12/2021 | AS Cannes [Youth] | - | Nîmes Olympique [Youth] | 6:1 |
France