| 1. Round | 07/08/2021 | FC Lorient B | - | AS Vitré | 1:0 | ||||
| 2. Round | 14/08/2021 | AS Vitré | - | EA Guingamp B | 0:4 | ||||
| 3. Round | 21/08/2021 | AS Poissy | - | AS Vitré | 3:0 | ||||
| 4. Round | 28/08/2021 | AS Vitré | - | C'Chartres Football | 0:1 | ||||
| 5. Round | 04/09/2021 | Châteaubriant Voltigeurs | - | AS Vitré | 1:0 | ||||
| 6. Round | 11/09/2021 | AS Vitré | - | Vannes OC | 0:1 | ||||
| 7. Round | 18/09/2021 | US Granvillaise | - | AS Vitré | 1:1 | ||||
| 8. Round | 25/09/2021 | AS Vitré | - | SO Romorantin | 1:1 | ||||
| 9. Round | 09/10/2021 | FC Rouen 1899 | - | AS Vitré | 1:1 |  |
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| 10. Round | 23/10/2021 | SM Caen B | - | AS Vitré | 1:0 |  |
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| 11. Round | 06/11/2021 | AS Vitré | - | FC Versailles | 1:2 | ||||
| 12. Round | 20/11/2021 | US Saint-Malo | - | AS Vitré | 1:0 |  |
France