| 1. Round | 07/08/2021 | Olympique Lyonnais B | - | AS Monaco B | 1:0 | ||||
| 2. Round | 14/08/2021 | AS Monaco B | - | RC Grasse | 0:1 | ||||
| 4. Round | 28/08/2021 | AS Monaco B | - | Hyères FC | 0:1 | ||||
| 7. Round | 18/09/2021 | AS Monaco B | - | FC Martigues | 2:0 | ||||
| 8. Round | 25/09/2021 | GFA Rumilly Vallières | - | AS Monaco B | 1:2 | ||||
| 9. Round | 09/10/2021 | AS Monaco B | - | AS Saint-Priest | 4:2 |  |
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| 10. Round | 23/10/2021 | Étoile FC | - | AS Monaco B | 1:1 | ||||
| 11. Round | 06/11/2021 | AS Monaco B | - | GOAL FC | 0:2 | ||||
| 13. Round | 04/12/2021 | AS Monaco B | - | Jura Sud | 1:1 | ||||
| 14. Round | 11/12/2021 | Olympique Marseille B | - | AS Monaco B | 0:1 | ||||
| 16. Round | 22/01/2022 | RC Grasse | - | AS Monaco B | 0:0 | ||||
| 17. Round | 05/02/2022 | AS Monaco B | - | Louhans-Cuiseaux | 1:1 | |
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| 19. Round | 19/02/2022 | AS Monaco B | - | Lyon-La Duchère | 2:2 | ||||
| 20. Round | 05/03/2022 | AS Monaco B | - | SC Toulon | 0:1 | |
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| 30. Round | 28/05/2022 | AS Monaco B | - | Olympique Lyonnais B | 4:1 |
Guadeloupe
France