| 1. Round | 07/08/2021 | Andrézieux-Bouthéon FC | - | Angers SCO B | 3:1 | ||||
| 2. Round | 14/08/2021 | Angers SCO B | - | US Colomiers | 0:0 | ||||
| 4. Round | 28/08/2021 | Angers SCO B | - | Canet Roussillon | 2:0 | ||||
| 5. Round | 03/09/2021 | Angoulême CFC | - | Angers SCO B | 4:0 | ||||
| 6. Round | 11/09/2021 | Angers SCO B | - | Trélissac FC | 0:1 | ||||
| 7. Round | 18/09/2021 | Moulins Yzeure Foot | - | Angers SCO B | 0:0 | ||||
| 3. Round | 02/10/2021 | FC Nantes B | - | Angers SCO B | 1:1 | ||||
| 9. Round | 09/10/2021 | Stade Montois | - | Angers SCO B | 0:4 | ||||
| 16. Round | 22/01/2022 | US Colomiers | - | Angers SCO B | 0:0 | ||||
| 20. Round | 05/03/2022 | Trélissac FC | - | Angers SCO B | 1:1 | ||||
| 21. Round | 12/03/2022 | Angers SCO B | - | Moulins Yzeure Foot | 1:1 | ||||
| 22. Round | 19/03/2022 | AS Béziers | - | Angers SCO B | 1:1 | ||||
| 23. Round | 26/03/2022 | Angers SCO B | - | Stade Montois | 0:0 | ||||
| 25. Round | 16/04/2022 | Angers SCO B | - | Le Puy Foot 43 | 0:2 |
France