| 4. Round | 28/08/2021 | US Saint-Malo | - | EA Guingamp B | 0:2 | ||||
| 5. Round | 04/09/2021 | EA Guingamp B | - | Stade Plabennec | 2:1 | ||||
| 11. Round | 06/11/2021 | C'Chartres Football | - | EA Guingamp B | 1:2 |  |
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| 12. Round | 20/11/2021 | EA Guingamp B | - | Châteaubriant Voltigeurs | 2:3 | ||||
| 17. Round | 05/02/2022 | FC Versailles | - | EA Guingamp B | 1:1 | ||||
| 18. Round | 12/02/2022 | EA Guingamp B | - | US Saint-Malo | 0:0 | ||||
| 20. Round | 05/03/2022 | EA Guingamp B | - | St-Pryvé St-Hilaire | 1:1 | ||||
| 23. Round | 26/03/2022 | SM Caen B | - | EA Guingamp B | 0:2 | |
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| 26. Round | 23/04/2022 | Châteaubriant Voltigeurs | - | EA Guingamp B | 0:2 | ||||
| 27. Round | 30/04/2022 | EA Guingamp B | - | Vannes OC | 1:0 |
France