| 2. Round | 25/07/2021 | Rosario Central | - | Vélez Sarsfield | 1:0 | ||||
| 3. Round | 29/07/2021 | Gimnasia de La Plata | - | Rosario Central | 1:0 | ||||
| 4. Round | 02/08/2021 | Rosario Central | - | Aldosivi | 1:2 | ||||
| 5. Round | 06/08/2021 | Sarmiento de Junín | - | Rosario Central | 1:0 | ||||
| 6. Round | 15/08/2021 | Rosario Central | - | Independiente | 1:2 | ||||
| 8. Round | 25/08/2021 | Rosario Central | - | Arsenal de Sarandí | 4:0 | ||||
| 9. Round | 29/08/2021 | Central Córdoba SdE | - | Rosario Central | 2:4 | ||||
| 12. Round | 20/09/2021 | Rosario Central | - | San Lorenzo | 1:0 |  |
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| 13. Round | 25/09/2021 | Talleres de Córdoba | - | Rosario Central | 4:1 | ||||
| 14. Round | 03/10/2021 | Rosario Central | - | Argentinos Juniors | 0:1 | ||||
| 17. Round | 19/10/2021 | Platense | - | Rosario Central | 1:1 | ||||
| 18. Round | 24/10/2021 | Rosario Central | - | Racing Club | 2:1 | ||||
| 21. Round | 20/11/2021 | Rosario Central | - | Atlético Tucumán | 3:1 | ||||
| 24. Round | 05/12/2021 | Lanús | - | Rosario Central | 2:2 | ||||
| 25. Round | 11/12/2021 | Rosario Central | - | Huracán | 1:4 | |
Mexico
Argentina