| Group A | 21/04/2021 | 12 de Octubre de Itauguá | - | Rosario Central | 1:0 | ||||
| Group A | 29/04/2021 | Rosario Central | - | San Lorenzo | 2:0 | ||||
| Group A | 05/05/2021 | Huachipato | - | Rosario Central | 1:1 |  |
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| Group A | 20/05/2021 | Rosario Central | - | Huachipato | 5:0 |  |
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| Group A | 27/05/2021 | Rosario Central | - | 12 de Octubre de Itauguá | 0:0 | ||||
| Round of 16 | 16/07/2021 | Deportivo Táchira | - | Rosario Central | 2:2 | ||||
| Round of 16 | 23/07/2021 | Rosario Central | - | Deportivo Táchira | 1:0 | ||||
| Quarter-finals | 10/08/2021 | Rosario Central | - | Red Bull Bragantino | 3:4 |
Mexico
Argentina