| 3. Round | 26/08/2018 | Lille OSC | - | EA Guingamp | 3:0 | ||||
| 4. Round | 01/09/2018 | EA Guingamp | - | Toulouse FC | 1:2 |  |
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| 7. Round | 26/09/2018 | Nîmes Olympique | - | EA Guingamp | 0:0 | ||||
| 8. Round | 29/09/2018 | Angers SCO | - | EA Guingamp | 0:1 | ||||
| 9. Round | 06/10/2018 | EA Guingamp | - | Montpellier HSC | 1:1 | ||||
| 13. Round | 10/11/2018 | EA Guingamp | - | Olympique Lyonnais | 2:4 | ||||
| 18. Round | 16/01/2019 | EA Guingamp | - | Stade Rennais | 2:1 |  |
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| 21. Round | 19/01/2019 | Paris Saint-Germain | - | EA Guingamp | 9:0 | ||||
| 22. Round | 26/01/2019 | EA Guingamp | - | Stade de Reims | 0:1 | ||||
| 25. Round | 15/02/2019 | Olympique Lyonnais | - | EA Guingamp | 2:1 | ||||
| 23. Round | 20/02/2019 | Girondins Bordeaux | - | EA Guingamp | 0:0 | |
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| 26. Round | 23/02/2019 | EA Guingamp | - | Angers SCO | 1:0 | |
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| 27. Round | 03/03/2019 | EA Guingamp | - | FC Nantes | 0:0 | ||||
| 28. Round | 10/03/2019 | Toulouse FC | - | EA Guingamp | 1:0 | ||||
| 29. Round | 16/03/2019 | EA Guingamp | - | Dijon FCO | 1:0 | ||||
| 32. Round | 13/04/2019 | RC Strasbourg | - | EA Guingamp | 3:3 | |
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| 36. Round | 12/05/2019 | Stade Rennais | - | EA Guingamp | 1:1 | ||||
| 38. Round | 24/05/2019 | Amiens SC | - | EA Guingamp | 2:1 |
France
