| 1. Round | 07/08/2021 | EA Guingamp B | - | FC Rouen 1899 | 0:0 | ||||
| 3. Round | 21/08/2021 | EA Guingamp B | - | FC Versailles | 0:3 | ||||
| 4. Round | 28/08/2021 | US Saint-Malo | - | EA Guingamp B | 0:2 |  |
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| 5. Round | 04/09/2021 | EA Guingamp B | - | Stade Plabennec | 2:1 | ||||
| 12. Round | 20/11/2021 | EA Guingamp B | - | Châteaubriant Voltigeurs | 2:3 | ||||
| 14. Round | 11/12/2021 | EA Guingamp B | - | US Granvillaise | 1:0 | ||||
| 15. Round | 15/01/2022 | SO Romorantin | - | EA Guingamp B | 2:3 | ||||
| 13. Round | 26/01/2022 | Vannes OC | - | EA Guingamp B | 2:0 | ||||
| 17. Round | 05/02/2022 | FC Versailles | - | EA Guingamp B | 1:1 | ||||
| 19. Round | 19/02/2022 | Stade Plabennec | - | EA Guingamp B | 1:0 | ||||
| 28. Round | 14/05/2022 | US Granvillaise | - | EA Guingamp B | 3:4 |
France