| 1. Round | 04/06/2022 | San Lorenzo | - | Independiente | 1:1 |  |
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| 2. Round | 11/06/2022 | Independiente | - | Talleres de Córdoba | 1:0 | ||||
| 3. Round | 16/06/2022 | Argentinos Juniors | - | Independiente | 2:1 | |
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| 4. Round | 21/06/2022 | Independiente | - | Estudiantes | 2:1 | ||||
| 5. Round | 27/06/2022 | Patronato de Paraná | - | Independiente | 3:1 | ||||
| 6. Round | 05/07/2022 | Independiente | - | Platense | 1:3 |  |
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| 7. Round | 10/07/2022 | Racing Club | - | Independiente | 1:0 | |
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| 8. Round | 16/07/2022 | Independiente | - | Rosario Central | 0:0 | ||||
| 9. Round | 20/07/2022 | Defensa y Justicia | - | Independiente | 2:1 | |
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| 11. Round | 02/08/2022 | Colón de Santa Fe | - | Independiente | 0:3 | ||||
| 12. Round | 07/08/2022 | Independiente | - | River Plate | 0:1 | ||||
| 13. Round | 13/08/2022 | Lanús | - | Independiente | 1:1 | |
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| 15. Round | 21/08/2022 | Godoy Cruz | - | Independiente | 1:1 | ||||
| 26. Round | 16/10/2022 | Independiente | - | Banfield | 1:0 | ||||
| 27. Round | 23/10/2022 | Boca Juniors | - | Independiente | 2:2 |
Argentina