| Group 4 | 22/04/2021 | Fluminense RJ | - | River Plate | 1:1 | ||||
| Group 4 | 29/04/2021 | Santa Fe | - | Fluminense RJ | 1:2 | ||||
| Group 4 | 07/05/2021 | Atlético Junior | - | Fluminense RJ | 1:1 | ||||
| Group 4 | 13/05/2021 | Fluminense RJ | - | Santa Fe | 2:1 |  |
|||
| Group 4 | 19/05/2021 | Fluminense RJ | - | Atlético Junior | 1:2 | ||||
| Group 4 | 25/05/2021 | River Plate | - | Fluminense RJ | 1:3 | ||||
| Round of 16 | 13/07/2021 | Cerro Porteño | - | Fluminense RJ | 0:2 | ||||
| Round of 16 | 03/08/2021 | Fluminense RJ | - | Cerro Porteño | 1:0 | ||||
| Quarter-finals | 13/08/2021 | Fluminense RJ | - | Barcelona | 2:2 | ||||
| Quarter-finals | 20/08/2021 | Barcelona | - | Fluminense RJ | 1:1 |
Brazil