| 3. Round | 18/10/2020 | Athletic Club [Women] | - | Real Betis [Women] | 2:2 | ||||
| 6. Round | 18/11/2020 | Rayo Vallecano [Women] | - | Real Betis [Women] | 1:0 | ||||
| 9. Round | 21/11/2020 | Real Betis [Women] | - | Real Madrid [Women] | 0:3 | ||||
| 11. Round | 13/12/2020 | Real Betis [Women] | - | Levante UD [Women] | 0:2 | ||||
| 12. Round | 19/12/2020 | Real Betis [Women] | - | EDF Logroño [Women] | 1:3 | ||||
| 13. Round | 22/12/2020 | Espanyol Barcelona [Women] | - | Real Betis [Women] | 2:1 | ||||
| 14. Round | 06/01/2021 | Real Betis [Women] | - | Sevilla FC [Women] | 0:2 | ||||
| 16. Round | 23/01/2021 | Real Betis [Women] | - | Madrid CFF [Women] | 1:2 | ||||
| 20. Round | 10/02/2021 | FC Barcelona [Women] | - | Real Betis [Women] | 6:0 | ||||
| 27. Round | 24/04/2021 | Real Betis [Women] | - | Real Sociedad [Women] | 2:2 | ||||
| 30. Round | 15/05/2021 | Valencia CF [Women] | - | Real Betis [Women] | 1:2 | ||||
| 32. Round | 05/06/2021 | Sevilla FC [Women] | - | Real Betis [Women] | 2:0 |
Spain