| 1. Round | 06/08/2022 | RC Strasbourg | - | AS Monaco | 1:2 | ||||
| 2. Round | 14/08/2022 | OGC Nice | - | RC Strasbourg | 1:1 | ||||
| 3. Round | 21/08/2022 | RC Strasbourg | - | Stade de Reims | 1:1 | ||||
| 4. Round | 27/08/2022 | AJ Auxerre | - | RC Strasbourg | 1:0 | ||||
| 5. Round | 31/08/2022 | RC Strasbourg | - | FC Nantes | 1:1 | ||||
| 6. Round | 04/09/2022 | Stade Brestois 29 | - | RC Strasbourg | 1:1 |  |
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| 7. Round | 11/09/2022 | RC Strasbourg | - | Clermont Foot 63 | 0:0 |  |
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| 13. Round | 29/10/2022 | RC Strasbourg | - | Olympique Marseille | 2:2 | ||||
| 14. Round | 05/11/2022 | AC Ajaccio | - | RC Strasbourg | 4:2 | ||||
| 15. Round | 13/11/2022 | RC Strasbourg | - | FC Lorient | 1:1 | ||||
| 16. Round | 28/12/2022 | Paris Saint-Germain | - | RC Strasbourg | 2:1 | ||||
| 17. Round | 02/01/2023 | RC Strasbourg | - | ESTAC Troyes | 2:3 | ||||
| 18. Round | 11/01/2023 | RC Strasbourg | - | RC Lens | 2:2 |
Réunion