| 1. Round | 01/09/1990 | Real Oviedo | - | Sevilla FC | 0:0 | ||||
| 2. Round | 07/09/1990 | Sevilla FC | - | Real Madrid | 2:0 | ||||
| 3. Round | 15/09/1990 | Espanyol Barcelona | - | Sevilla FC | 4:0 | ||||
| 22. Round | 09/02/1991 | Sevilla FC | - | Espanyol Barcelona | 1:1 |  |
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| 23. Round | 22/02/1991 | Valencia CF | - | Sevilla FC | 2:1 | ||||
| 24. Round | 01/03/1991 | Sevilla FC | - | Real Betis | 3:2 | ||||
| 25. Round | 09/03/1991 | Real Valladolid | - | Sevilla FC | 2:1 | |
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| 26. Round | 16/03/1991 | Sevilla FC | - | CD Tenerife | 2:2 | ||||
| 27. Round | 23/03/1991 | Athletic Club | - | Sevilla FC | 2:0 | ||||
| 28. Round | 30/03/1991 | Sevilla FC | - | CA Osasuna | 2:1 | ||||
| 29. Round | 05/04/1991 | Sporting Gijón | - | Sevilla FC | 2:0 | ||||
| 30. Round | 12/04/1991 | Sevilla FC | - | Atlético Madrid | 1:1 | ||||
| 31. Round | 19/04/1991 | FC Barcelona | - | Sevilla FC | 3:0 | ||||
| 32. Round | 27/04/1991 | Sevilla FC | - | CD Castellón | 3:0 |  |
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| 33. Round | 04/05/1991 | Real Burgos | - | Sevilla FC | 1:1 | ||||
| 34. Round | 11/05/1991 | RCD Mallorca | - | Sevilla FC | 1:1 | |
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| 38. Round | 07/06/1991 | CD Logroñés | - | Sevilla FC | 2:1 | |
Spain
