| 1. Round | 29/08/2021 | RB Linense | - | Real Madrid Castilla | 2:1 | ||||
| 4. Round | 19/09/2021 | Real Madrid Castilla | - | Gimnàstic de Tarragona | 2:1 | ||||
| 5. Round | 26/09/2021 | Albacete | - | Real Madrid Castilla | 2:0 | ||||
| 7. Round | 08/10/2021 | UE Cornellà | - | Real Madrid Castilla | 1:0 | ||||
| 10. Round | 29/10/2021 | Real Madrid Castilla | - | Villarreal CF B | 2:1 | ||||
| 11. Round | 06/11/2021 | UE Costa Brava | - | Real Madrid Castilla | 0:1 | ||||
| 12. Round | 14/11/2021 | Real Madrid Castilla | - | Algeciras CF | 2:0 | ||||
| 15. Round | 05/12/2021 | Real Madrid Castilla | - | CD Castellón | 1:2 | ||||
| 16. Round | 11/12/2021 | Sevilla Atlético | - | Real Madrid Castilla | 1:1 | ||||
| 17. Round | 18/12/2021 | Real Betis B | - | Real Madrid Castilla | 0:3 | ||||
| 20. Round | 08/03/2022 | Real Madrid Castilla | - | Albacete | 0:1 | ||||
| 27. Round | 13/03/2022 | Real Madrid Castilla | - | Atlético Sanluqueño CF | 5:2 | ||||
| 36. Round | 15/05/2022 | Real Madrid Castilla | - | UE Costa Brava | 5:1 | ||||
| 37. Round | 21/05/2022 | Algeciras CF | - | Real Madrid Castilla | 1:1 |
Spain