| 1. Round | 29/08/2021 | La Roche VF [Youth B] | - | CPBB Rennes [Youth B] | 3:1 | ||||
| 2. Round | 04/09/2021 | USSA Vertou [Youth B] | - | CPBB Rennes [Youth B] | 1:1 | ||||
| 3. Round | 12/09/2021 | CPBB Rennes [Youth B] | - | Angoulême CFC [Youth B] | 0:2 |  |
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| 4. Round | 18/09/2021 | Vannes OC [Youth B] | - | CPBB Rennes [Youth B] | 1:0 | ||||
| 7. Round | 09/10/2021 | CPBB Rennes [Youth B] | - | LB Châteauroux [Youth B] | 2:7 | ||||
| 9. Round | 23/10/2021 | CPBB Rennes [Youth B] | - | FC Lorient [Youth B] | 0:3 | ||||
| 20. Round | 19/03/2022 | CPBB Rennes [Youth B] | - | SO Cholet [Youth B] | 1:4 | ||||
| 21. Round | 26/03/2022 | FC Lorient [Youth B] | - | CPBB Rennes [Youth B] | 4:1 | ||||
| 23. Round | 09/04/2022 | Stade brestois 29 [Youth B] | - | CPBB Rennes [Youth B] | 2:0 | ||||
| 24. Round | 16/04/2022 | CPBB Rennes [Youth B] | - | Chamois Niortais [Youth B] | 1:4 | ||||
| 25. Round | 01/05/2022 | EA Guingamp [Youth B] | - | CPBB Rennes [Youth B] | 2:0 | ||||
| 26. Round | 15/05/2022 | CPBB Rennes [Youth B] | - | La Roche VF [Youth B] | abor. |
France