| 12. Round | 27/11/2021 | Stade de Reims [Youth B] | - | RC Lens [Youth B] | 1:1 | ||||
| 13. Round | 05/12/2021 | Stade de Reims [Youth B] | - | Amiens SC [Youth B] | 0:2 | ||||
| 14. Round | 15/01/2022 | US Boulogne [Youth B] | - | Stade de Reims [Youth B] | 0:4 |  |
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| 15. Round | 23/01/2022 | Stade de Reims [Youth B] | - | Entente Feignies Aulnoye [Youth B] | 2:0 | |
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| 16. Round | 05/02/2022 | Valenciennes FC [Youth B] | - | Stade de Reims [Youth B] | 0:1 | ||||
| 17. Round | 13/02/2022 | Stade de Reims [Youth B] | - | Paris 13 Atletico [Youth B] | 2:2 | ||||
| 18. Round | 06/03/2022 | USL Dunkerque [Youth B] | - | Stade de Reims [Youth B] | 0:2 | ||||
| 19. Round | 13/03/2022 | Stade de Reims [Youth B] | - | JA Drancy [Youth B] | 3:0 | ||||
| 20. Round | 30/03/2022 | US Torcy [Youth B] | - | Stade de Reims [Youth B] | 0:3 | |
France
Senegal