| 1. Round | 12/09/2020 | SD Ponferradina | - | CD Castellón | 1:2 | ||||
| 2. Round | 20/09/2020 | Albacete | - | SD Ponferradina | 0:2 |  |
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| 3. Round | 27/09/2020 | SD Ponferradina | - | Rayo Vallecano | 3:0 | |
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| 4. Round | 03/10/2020 | CD Mirandés | - | SD Ponferradina | 0:1 | ||||
| 7. Round | 21/10/2020 | SD Ponferradina | - | CD Tenerife | 1:0 | |
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| 8. Round | 25/10/2020 | Sporting Gijón | - | SD Ponferradina | 2:1 | ||||
| 9. Round | 28/10/2020 | Espanyol Barcelona | - | SD Ponferradina | 2:0 | ||||
| 10. Round | 01/11/2020 | SD Ponferradina | - | CE Sabadell | 0:3 | ||||
| 6. Round | 05/11/2020 | AD Alcorcón | - | SD Ponferradina | 0:1 | ||||
| 11. Round | 08/11/2020 | RCD Mallorca | - | SD Ponferradina | 3:0 | ||||
| 13. Round | 22/11/2020 | SD Ponferradina | - | Real Zaragoza | 2:1 | |
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| 14. Round | 25/11/2020 | CF Fuenlabrada | - | SD Ponferradina | 1:1 | ||||
| 19. Round | 18/12/2020 | SD Ponferradina | - | Real Oviedo | 1:0 | ||||
| 20. Round | 03/01/2021 | UD Almería | - | SD Ponferradina | 3:1 |
Spain