| 2. Round | 21/08/2021 | Granada CF | - | Valencia CF | 1:1 | ||||
| 6. Round | 22/09/2021 | Sevilla FC | - | Valencia CF | 3:1 | ||||
| 7. Round | 25/09/2021 | Valencia CF | - | Athletic Club | 1:1 |  |
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| 8. Round | 02/10/2021 | Cádiz CF | - | Valencia CF | 0:0 | ||||
| 9. Round | 17/10/2021 | FC Barcelona | - | Valencia CF | 3:1 | ||||
| 10. Round | 23/10/2021 | Valencia CF | - | RCD Mallorca | 2:2 | |
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| 11. Round | 27/10/2021 | Real Betis | - | Valencia CF | 4:1 | |
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| 13. Round | 07/11/2021 | Valencia CF | - | Atlético Madrid | 3:3 | ||||
| 20. Round | 08/01/2022 | Real Madrid | - | Valencia CF | 4:1 |
Spain