| 12. Round | 25/09/1980 | Stade Lavallois | - | AS Monaco | 3:3 | ||||
| 13. Round | 04/10/1980 | AS Monaco | - | FC Sochaux | 2:1 | ||||
| 15. Round | 17/10/1980 | AS Monaco | - | FC Nantes | 2:1 |  |
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| 19. Round | 22/11/1980 | AS Monaco | - | OGC Nice | 1:0 | ||||
| 20. Round | 28/11/1980 | Lille OSC | - | AS Monaco | 2:1 | ||||
| 21. Round | 06/12/1980 | AS Monaco | - | Olympique Lyonnais | 2:1 | ||||
| 22. Round | 12/12/1980 | Angers SCO | - | AS Monaco | 1:1 | ||||
| 24. Round | 24/01/1981 | Paris Saint-Germain | - | AS Monaco | 0:0 | ||||
| 26. Round | 07/02/1981 | US Valenciennes-Anzin | - | AS Monaco | 0:1 | ||||
| 28. Round | 27/02/1981 | AS Monaco | - | FC Metz | 2:1 | ||||
| 29. Round | 13/03/1981 | AS Saint-Étienne | - | AS Monaco | 5:1 | |
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| 30. Round | 27/03/1981 | AS Monaco | - | Stade Lavallois | 3:0 | ||||
| 32. Round | 14/04/1981 | AS Monaco | - | RC Lens | 1:0 | ||||
| 33. Round | 20/04/1981 | FC Nantes | - | AS Monaco | 5:0 | ||||
| 34. Round | 04/05/1981 | AS Monaco | - | Nîmes Olympique | 2:1 | ||||
| 35. Round | 11/05/1981 | Tours FC | - | AS Monaco | 0:1 | |
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| 36. Round | 21/05/1981 | AS Monaco | - | Girondins Bordeaux | 0:0 | ||||
| 38. Round | 01/06/1981 | AS Monaco | - | AS Nancy Lorraine | 1:0 |
France