| 5. Round | 18/08/1980 | Paris Saint-Germain | - | US Valenciennes-Anzin | 3:2 | ||||
| 9. Round | 08/09/1980 | US Valenciennes-Anzin | - | FC Metz | 3:0 | ||||
| 15. Round | 17/10/1980 | US Valenciennes-Anzin | - | Stade Lavallois | 4:2 | ||||
| 16. Round | 30/10/1980 | Tours FC | - | US Valenciennes-Anzin | 2:3 |  |
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| 17. Round | 07/11/1980 | US Valenciennes-Anzin | - | Girondins Bordeaux | 2:2 | ||||
| 20. Round | 29/11/1980 | SÉC Bastia | - | US Valenciennes-Anzin | 1:1 | ||||
| 28. Round | 27/02/1981 | US Valenciennes-Anzin | - | AS Saint-Étienne | 0:1 | ||||
| 29. Round | 13/03/1981 | Nîmes Olympique | - | US Valenciennes-Anzin | 1:1 | ||||
| 31. Round | 06/04/1981 | RC Lens | - | US Valenciennes-Anzin | 1:2 | ||||
| 32. Round | 14/04/1981 | US Valenciennes-Anzin | - | FC Sochaux | 2:1 | ||||
| 33. Round | 20/04/1981 | Stade Lavallois | - | US Valenciennes-Anzin | 2:1 | ||||
| 35. Round | 11/05/1981 | Girondins Bordeaux | - | US Valenciennes-Anzin | 4:0 | ||||
| 36. Round | 21/05/1981 | US Valenciennes-Anzin | - | OGC Nice | 1:0 | ||||
| 37. Round | 28/05/1981 | AS Nancy Lorraine | - | US Valenciennes-Anzin | 7:1 | ||||
| 38. Round | 01/06/1981 | US Valenciennes-Anzin | - | Olympique Lyonnais | 2:1 |
France