| 5. Round | 26/09/2021 | Atlético Baleares | - | Real Betis B | 1:0 | ||||
| 6. Round | 03/10/2021 | Real Betis B | - | Atlético Sanluqueño CF | 0:3 | ||||
| 7. Round | 09/10/2021 | Albacete | - | Real Betis B | 1:1 | ||||
| 8. Round | 16/10/2021 | Real Betis B | - | Villarreal CF B | 1:2 | ||||
| 14. Round | 27/11/2021 | CD Castellón | - | Real Betis B | 2:1 | ||||
| 15. Round | 04/12/2021 | Real Betis B | - | Linares Deportivo | 1:3 | ||||
| 19. Round | 16/02/2022 | Real Betis B | - | Sevilla Atlético | 0:1 | ||||
| 29. Round | 27/03/2022 | Real Betis B | - | FC Barcelona B | 1:2 | ||||
| 30. Round | 03/04/2022 | UCAM Murcia CF | - | Real Betis B | 1:0 | ||||
| 31. Round | 09/04/2022 | Real Betis B | - | CE Sabadell | 0:4 | ||||
| 32. Round | 17/04/2022 | RB Linense | - | Real Betis B | 1:0 | ||||
| 34. Round | 30/04/2022 | Real Betis B | - | FC Andorra | 3:2 | ||||
| 35. Round | 06/05/2022 | Real Betis B | - | CD Alcoyano | 3:2 | ||||
| 36. Round | 14/05/2022 | Atlético Sanluqueño CF | - | Real Betis B | 1:0 | ||||
| 38. Round | 27/05/2022 | Real Madrid Castilla | - | Real Betis B | 4:0 |
Spain