| 1. Round | 16/07/2021 | Unión de Santa Fe | - | Boca Juniors | 1:1 |  |
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| 4. Round | 01/08/2021 | Talleres de Córdoba | - | Boca Juniors | 0:0 | ||||
| 5. Round | 08/08/2021 | Boca Juniors | - | Argentinos Juniors | 1:1 | ||||
| 9. Round | 30/08/2021 | Boca Juniors | - | Racing Club | 0:0 | ||||
| 10. Round | 05/09/2021 | Rosario Central | - | Boca Juniors | 1:2 | ||||
| 11. Round | 15/09/2021 | Boca Juniors | - | Defensa y Justicia | 0:0 | ||||
| 15. Round | 10/10/2021 | Boca Juniors | - | Lanús | 4:2 |  |
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| 16. Round | 17/10/2021 | Huracán | - | Boca Juniors | 0:3 | |
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| 17. Round | 21/10/2021 | Boca Juniors | - | Godoy Cruz | 2:1 | ||||
| 18. Round | 25/10/2021 | Vélez Sarsfield | - | Boca Juniors | 2:0 |
Argentina