| 1. Round | 19/07/2021 | Independiente | - | Argentinos Juniors | 0:0 |  |
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| 15. Round | 09/10/2021 | Argentinos Juniors | - | Defensa y Justicia | 0:2 | ||||
| 17. Round | 21/10/2021 | Argentinos Juniors | - | Colón de Santa Fe | 3:1 | ||||
| 23. Round | 28/11/2021 | Argentinos Juniors | - | Gimnasia de La Plata | 3:0 | ||||
| 24. Round | 06/12/2021 | Aldosivi | - | Argentinos Juniors | 3:2 |
Argentina
Italy