| 1. Round | 04/09/2021 | CA Osasuna B | - | CD Tropezón | 2:0 | ||||
| 2. Round | 12/09/2021 | CD Tropezón | - | SD Gernika | 0:2 | ||||
| 3. Round | 18/09/2021 | UD Logroñés Promesas | - | CD Tropezón | 4:1 | ||||
| 5. Round | 02/10/2021 | CD Izarra | - | CD Tropezón | 2:2 | ||||
| 7. Round | 17/10/2021 | CD Tropezón | - | CD Laredo | 1:0 | ||||
| 8. Round | 24/10/2021 | Real Sociedad C | - | CD Tropezón | 5:0 | ||||
| 9. Round | 30/10/2021 | CD Tropezón | - | AD San Juan | 3:4 | ||||
| 10. Round | 07/11/2021 | Arenas de Getxo | - | CD Tropezón | 2:1 | ||||
| 12. Round | 21/11/2021 | Racing Rioja CF | - | CD Tropezón | 4:0 | ||||
| 14. Round | 05/12/2021 | Peña Sport FC | - | CD Tropezón | 2:1 |
Spain