| 1. Round | 02/06/2022 | Newell's Old Boys II | - | Banfield II | 1:0 | ||||
| 2. Round | 09/06/2022 | San Lorenzo II | - | Newell's Old Boys II | 2:3 | ||||
| 3. Round | 15/06/2022 | Newell's Old Boys II | - | Talleres de Córdoba II | 0:0 | ||||
| 4. Round | 20/06/2022 | Argentinos Juniors II | - | Newell's Old Boys II | 1:0 | ||||
| 5. Round | 25/06/2022 | Newell's Old Boys II | - | Estudiantes II | 0:0 | ||||
| 6. Round | 04/07/2022 | Patronato de Paraná II | - | Newell's Old Boys II | 0:0 | ||||
| 7. Round | 09/07/2022 | Newell's Old Boys II | - | Platense II | 3:0 | ||||
| 8. Round | 14/07/2022 | Racing Club II | - | Newell's Old Boys II | 4:4 | ||||
| 9. Round | 18/07/2022 | Newell's Old Boys II | - | Rosario Central II | 2:1 |  |
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| 11. Round | 28/07/2022 | Newell's Old Boys II | - | Atlético Tucumán II | 0:0 | ||||
| 12. Round | 06/08/2022 | Colón de Santa Fe II | - | Newell's Old Boys II | 0:2 | ||||
| 13. Round | 11/08/2022 | Newell's Old Boys II | - | River Plate II | 2:0 | ||||
| 14. Round | 15/08/2022 | Lanús II | - | Newell's Old Boys II | 2:0 | ||||
| 24. Round | 09/10/2022 | Newell's Old Boys II | - | Central Córdoba SdE II | 0:0 | ||||
| 27. Round | 22/10/2022 | Newell's Old Boys II | - | Barracas Central II | 3:0 |
Argentina