| 1. Round | 04/06/2022 | Banfield | - | Newell's Old Boys | 1:2 | ||||
| 2. Round | 10/06/2022 | Newell's Old Boys | - | San Lorenzo | 0:0 | ||||
| 3. Round | 14/06/2022 | Talleres de Córdoba | - | Newell's Old Boys | 0:1 | ||||
| 4. Round | 21/06/2022 | Newell's Old Boys | - | Argentinos Juniors | 1:0 | ||||
| 5. Round | 25/06/2022 | Estudiantes | - | Newell's Old Boys | 0:2 | ||||
| 7. Round | 10/07/2022 | Platense | - | Newell's Old Boys | 1:1 | ||||
| 12. Round | 08/08/2022 | Newell's Old Boys | - | Colón de Santa Fe | 0:0 |  |
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| 14. Round | 17/08/2022 | Newell's Old Boys | - | Lanús | 2:0 | ||||
| 15. Round | 21/08/2022 | Huracán | - | Newell's Old Boys | 1:0 | ||||
| 16. Round | 27/08/2022 | Newell's Old Boys | - | Godoy Cruz | 1:2 | ||||
| 17. Round | 03/09/2022 | Vélez Sarsfield | - | Newell's Old Boys | 0:1 | ||||
| 23. Round | 04/10/2022 | Newell's Old Boys | - | Arsenal de Sarandí | 0:0 | ||||
| 24. Round | 11/10/2022 | Central Córdoba SdE | - | Newell's Old Boys | 0:3 | ||||
| 26. Round | 16/10/2022 | Newell's Old Boys | - | Boca Juniors | 2:0 | ||||
| 27. Round | 24/10/2022 | Barracas Central | - | Newell's Old Boys | 1:1 |
Argentina