| 4. Round | 29/09/2021 | Valencia CF [Women] | - | Athletic Club [Women] | 1:3 | ||||
| 5. Round | 03/10/2021 | Athletic Club [Women] | - | Real Madrid [Women] | 2:0 | ||||
| 7. Round | 17/10/2021 | Athletic Club [Women] | - | Villarreal CF [Women] | 2:1 | ||||
| 10. Round | 14/11/2021 | Rayo Vallecano [Women] | - | Athletic Club [Women] | 0:2 | ||||
| 19. Round | 30/01/2022 | Athletic Club [Women] | - | Rayo Vallecano [Women] | 2:1 | ||||
| 20. Round | 02/02/2022 | Athletic Club [Women] | - | SD Eibar [Women] | 3:1 | ||||
| 21. Round | 06/02/2022 | Sporting de Huelva [Women] | - | Athletic Club [Women] | 2:0 | ||||
| 23. Round | 05/03/2022 | Real Madrid [Women] | - | Athletic Club [Women] | 2:0 | ||||
| 24. Round | 12/03/2022 | Athletic Club [Women] | - | Madrid CFF [Women] | 2:1 | ||||
| 27. Round | 17/04/2022 | Atlético Madrid [Women] | - | Athletic Club [Women] | 3:0 | ||||
| 28. Round | 30/04/2022 | Athletic Club [Women] | - | UDG Tenerife Sur [Women] | 2:1 | ||||
| 29. Round | 07/05/2022 | CD Alavés [Women] | - | Athletic Club [Women] | 1:3 | ||||
| 30. Round | 15/05/2022 | Athletic Club [Women] | - | Sevilla FC [Women] | 1:4 |
Spain