| 5. Round | 26/09/2021 | Olympique Lyonnais [Youth B] | - | AJ Auxerre [Youth B] | 3:1 | ||||
| 6. Round | 03/10/2021 | FC Metz [Youth B] | - | Olympique Lyonnais [Youth B] | 0:3 | ||||
| 7. Round | 10/10/2021 | Olympique Lyonnais [Youth B] | - | FC Lyon [Youth B] | 2:2 | ||||
| 9. Round | 24/10/2021 | FC Annecy [Youth B] | - | Olympique Lyonnais [Youth B] | 2:1 | ||||
| 12. Round | 28/11/2021 | Olympique Lyonnais [Youth B] | - | SAS Épinal [Youth B] | 5:0 | ||||
| 13. Round | 05/12/2021 | AS Nancy Lorraine [Youth B] | - | Olympique Lyonnais [Youth B] | 0:1 | ||||
| 14. Round | 16/01/2022 | Olympique Lyonnais [Youth B] | - | ASPTT Dijon [Youth B] | 0:0 | ||||
| 19. Round | 30/03/2022 | FC Lyon [Youth B] | - | Olympique Lyonnais [Youth B] | 0:1 | ||||
| 22. Round | 03/04/2022 | Dijon FCO [Youth B] | - | Olympique Lyonnais [Youth B] | 2:2 | ||||
| 26. Round | 15/05/2022 | RC Strasbourg [Youth B] | - | Olympique Lyonnais [Youth B] | 1:3 |
France