| 1. Round | 22/08/2021 | FC Istres [Youth] | - | Pieve di Lota [Youth] | 7:0 | ||||
| 2. Round | 29/08/2021 | AS Saint-Étienne [Youth] | - | Pieve di Lota [Youth] | 11:0 | ||||
| 3. Round | 05/09/2021 | Pieve di Lota [Youth] | - | AS Monaco [Youth] | 0:9 | ||||
| 4. Round | 12/09/2021 | US Colomiers [Youth] | - | Pieve di Lota [Youth] | 7:2 |  |
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| 5. Round | 19/09/2021 | Pieve di Lota [Youth] | - | AC Ajaccio [Youth] | 1:3 | ||||
| 6. Round | 26/09/2021 | Nîmes Olympique [Youth] | - | Pieve di Lota [Youth] | 4:1 | ||||
| 7. Round | 03/10/2021 | Pieve di Lota [Youth] | - | Montpellier HSC [Youth] | 0:2 | ||||
| 8. Round | 10/10/2021 | AS Béziers [Youth] | - | Pieve di Lota [Youth] | 5:0 | ||||
| 10. Round | 24/10/2021 | Olympique Marseille [Youth] | - | Pieve di Lota [Youth] | 5:0 | ||||
| 14. Round | 05/12/2021 | Pieve di Lota [Youth] | - | AS Saint-Étienne [Youth] | 1:7 |
France