| 1. Round | 07/08/2021 | US Colomiers | - | Le Puy Foot 43 | 0:1 | ||||
| 2. Round | 14/08/2021 | Angers SCO B | - | US Colomiers | 0:0 | ||||
| 5. Round | 04/09/2021 | US Colomiers | - | FC Chamalières | 2:0 | ||||
| 6. Round | 11/09/2021 | Andrézieux-Bouthéon FC | - | US Colomiers | 0:1 | ||||
| 7. Round | 18/09/2021 | US Colomiers | - | Bergerac Périgord FC | 0:1 | ||||
| 8. Round | 25/09/2021 | US Colomiers | - | FC Nantes B | 0:2 | ||||
| 15. Round | 15/01/2022 | Bourges Foot 18 | - | US Colomiers | 4:1 | ||||
| 16. Round | 22/01/2022 | US Colomiers | - | Angers SCO B | 0:0 | ||||
| 19. Round | 19/02/2022 | FC Chamalières | - | US Colomiers | 2:0 | ||||
| 20. Round | 05/03/2022 | US Colomiers | - | Andrézieux-Bouthéon FC | 3:3 |
France