| 5. Round | 26/09/2021 | AS Monaco [Youth B] | - | AC Ajaccio [Youth B] | 1:4 | ||||
| 8. Round | 16/10/2021 | AC Ajaccio [Youth B] | - | Olympique Marseille [Youth B] | 1:1 |  |
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| 10. Round | 14/11/2021 | Castelnau Le Crès FC [Youth B] | - | AC Ajaccio [Youth B] | 0:2 | ||||
| 13. Round | 05/12/2021 | AC Ajaccio [Youth B] | - | AS Saint-Étienne [Youth B] | 3:1 | ||||
| 14. Round | 15/01/2022 | OGC Nice [Youth B] | - | AC Ajaccio [Youth B] | 1:1 | ||||
| 17. Round | 12/02/2022 | AC Ajaccio [Youth B] | - | AS Monaco [Youth B] | 4:1 | |
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| 15. Round | 26/02/2022 | AC Ajaccio [Youth B] | - | Clermont Foot 63 [Youth B] | 2:0 | ||||
| 20. Round | 20/03/2022 | Olympique Marseille [Youth B] | - | AC Ajaccio [Youth B] | 2:2 |
France