| 1. Round | 29/08/2021 | AS Monaco [Youth B] | - | Gazélec FC Ajaccio [Youth B] | 5:1 | ||||
| 4. Round | 19/09/2021 | Olympique Marseille [Youth B] | - | Gazélec FC Ajaccio [Youth B] | 1:1 | ||||
| 6. Round | 03/10/2021 | AC Ajaccio [Youth B] | - | Gazélec FC Ajaccio [Youth B] | 2:0 | ||||
| 10. Round | 13/11/2021 | AS Saint-Priest [Youth B] | - | Gazélec FC Ajaccio [Youth B] | 4:1 | ||||
| 11. Round | 20/11/2021 | Gazélec FC Ajaccio [Youth B] | - | OGC Nice [Youth B] | 1:0 | ||||
| 12. Round | 28/11/2021 | Clermont Foot 63 [Youth B] | - | Gazélec FC Ajaccio [Youth B] | 0:1 | ||||
| 13. Round | 05/12/2021 | Gazélec FC Ajaccio [Youth B] | - | SC Air Bel [Youth B] | 3:2 |  |
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| 14. Round | 15/01/2022 | Gazélec FC Ajaccio [Youth B] | - | Castelnau Le Crès FC [Youth B] | 1:0 | ||||
| 15. Round | 23/01/2022 | Andrézieux-Bouthéon FC [Youth B] | - | Gazélec FC Ajaccio [Youth B] | 4:0 | ||||
| 17. Round | 12/02/2022 | Olympique de Valence [Youth B] | - | Gazélec FC Ajaccio [Youth B] | 2:1 | ||||
| 19. Round | 13/03/2022 | Racing FC Toulon [Youth B] | - | Gazélec FC Ajaccio [Youth B] | 2:2 | |
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| 21. Round | 26/03/2022 | AS Saint-Étienne [Youth B] | - | Gazélec FC Ajaccio [Youth B] | 2:0 |
France