| 8. Round | 23/08/2021 | Estudiantes II | - | San Lorenzo II | 2:2 | ||||
| 16. Round | 15/10/2021 | River Plate II | - | San Lorenzo II | 1:3 | ||||
| 17. Round | 18/10/2021 | San Lorenzo II | - | Lanús II | 0:0 | ||||
| 18. Round | 22/10/2021 | Huracán II | - | San Lorenzo II | 0:1 | ||||
| 20. Round | 05/11/2021 | Vélez Sarsfield II | - | San Lorenzo II | 2:0 | ||||
| 3. Round | 11/11/2021 | Boca Juniors II | - | San Lorenzo II | 4:1 | ||||
| 23. Round | 27/11/2021 | San Lorenzo II | - | Sarmiento de Junín II | 3:1 | ||||
| 24. Round | 06/12/2021 | Independiente II | - | San Lorenzo II | 1:0 |
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