| 3. Round | 03/10/2020 | RB Leipzig | - | FC Schalke 04 | 4:0 |  |
|||
| 4. Round | 18/10/2020 | FC Schalke 04 | - | 1. FC Union Berlin | 1:1 | ||||
| 5. Round | 24/10/2020 | Borussia Dortmund | - | FC Schalke 04 | 3:0 | ||||
| 6. Round | 30/10/2020 | FC Schalke 04 | - | VfB Stuttgart | 1:1 | ||||
| 7. Round | 07/11/2020 | 1. FSV Mainz 05 | - | FC Schalke 04 | 2:2 | ||||
| 8. Round | 21/11/2020 | FC Schalke 04 | - | VfL Wolfsburg | 0:2 | ||||
| 9. Round | 28/11/2020 | Bor. Mönchengladbach | - | FC Schalke 04 | 4:1 | ||||
| 11. Round | 13/12/2020 | FC Augsburg | - | FC Schalke 04 | 2:2 | ||||
| 14. Round | 02/01/2021 | Hertha BSC | - | FC Schalke 04 | 3:0 | ||||
| 15. Round | 09/01/2021 | FC Schalke 04 | - | 1899 Hoffenheim | 4:0 | ||||
| 16. Round | 17/01/2021 | Eintracht Frankfurt | - | FC Schalke 04 | 3:1 | ||||
| 17. Round | 20/01/2021 | FC Schalke 04 | - | 1. FC Köln | 1:2 | ||||
| 18. Round | 24/01/2021 | FC Schalke 04 | - | Bayern München | 0:4 | |
|||
| 19. Round | 30/01/2021 | Werder Bremen | - | FC Schalke 04 | 1:1 | ||||
| 20. Round | 06/02/2021 | FC Schalke 04 | - | RB Leipzig | 0:3 |
Serbia
