| 5. Round | 02/09/2021 | FC Nantes B | - | Montpellier HSC B | 1:0 | ||||
| 8. Round | 25/09/2021 | Montpellier HSC B | - | Trélissac FC | 1:2 | ||||
| 9. Round | 09/10/2021 | Moulins Yzeure Foot | - | Montpellier HSC B | 1:2 | ||||
| 10. Round | 23/10/2021 | Montpellier HSC B | - | AS Béziers | 2:0 | ||||
| 11. Round | 06/11/2021 | Stade Montois | - | Montpellier HSC B | 1:2 | ||||
| 12. Round | 20/11/2021 | Montpellier HSC B | - | Bourges Foot 18 | 2:3 | ||||
| 16. Round | 22/01/2022 | FC Chamalières | - | Montpellier HSC B | 1:2 |  |
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| 17. Round | 05/02/2022 | Montpellier HSC B | - | Andrézieux-Bouthéon FC | 0:2 | ||||
| 20. Round | 05/03/2022 | Canet Roussillon | - | Montpellier HSC B | 0:1 | ||||
| 21. Round | 12/03/2022 | Montpellier HSC B | - | Angoulême CFC | 0:0 | ||||
| 22. Round | 19/03/2022 | Trélissac FC | - | Montpellier HSC B | 3:0 | |
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| 24. Round | 09/04/2022 | AS Béziers | - | Montpellier HSC B | 2:2 | ||||
| 26. Round | 23/04/2022 | Bourges Foot 18 | - | Montpellier HSC B | 2:1 | ||||
| 29. Round | 21/05/2022 | Montpellier HSC B | - | Vendée Les Herbiers | 1:0 | ||||
| 30. Round | 28/05/2022 | Bergerac Périgord FC | - | Montpellier HSC B | 2:1 |
France