| 14. Round | 11/12/2021 | Andrézieux-Bouthéon FC | - | Bourges Foot 18 | 2:1 | ||||
| 7. Round | 07/01/2022 | FC Nantes B | - | Andrézieux-Bouthéon FC | 1:0 | ||||
| 16. Round | 22/01/2022 | Andrézieux-Bouthéon FC | - | Vendée Les Herbiers | 1:2 |  |
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| 15. Round | 29/01/2022 | Le Puy Foot 43 | - | Andrézieux-Bouthéon FC | 0:0 | ||||
| 17. Round | 05/02/2022 | Montpellier HSC B | - | Andrézieux-Bouthéon FC | 0:2 | ||||
| 18. Round | 12/02/2022 | Andrézieux-Bouthéon FC | - | FC Chamalières | 0:0 | ||||
| 19. Round | 18/02/2022 | Bergerac Périgord FC | - | Andrézieux-Bouthéon FC | 0:0 | ||||
| 21. Round | 11/03/2022 | Andrézieux-Bouthéon FC | - | FC Nantes B | 3:1 | ||||
| 22. Round | 19/03/2022 | Canet Roussillon | - | Andrézieux-Bouthéon FC | 0:2 | ||||
| 23. Round | 25/03/2022 | Andrézieux-Bouthéon FC | - | Angoulême CFC | 1:0 | ||||
| 24. Round | 09/04/2022 | Trélissac FC | - | Andrézieux-Bouthéon FC | 0:1 | ||||
| 25. Round | 16/04/2022 | Andrézieux-Bouthéon FC | - | Moulins Yzeure Foot | 2:0 | ||||
| 26. Round | 22/04/2022 | AS Béziers | - | Andrézieux-Bouthéon FC | 3:1 | ||||
| 27. Round | 30/04/2022 | Andrézieux-Bouthéon FC | - | Stade Montois | 3:3 |
France