| 1. Round | 07/08/2021 | Blois Foot 41 | - | FC Versailles | 0:2 | ||||
| 2. Round | 14/08/2021 | US Saint-Malo | - | Blois Foot 41 | 1:2 | ||||
| 3. Round | 21/08/2021 | Blois Foot 41 | - | Stade Plabennec | 1:0 | ||||
| 4. Round | 28/08/2021 | St-Pryvé St-Hilaire | - | Blois Foot 41 | 0:1 | ||||
| 5. Round | 04/09/2021 | Blois Foot 41 | - | SM Caen B | 2:1 | ||||
| 6. Round | 11/09/2021 | Blois Foot 41 | - | FC Lorient B | 1:4 | ||||
| 7. Round | 18/09/2021 | EA Guingamp B | - | Blois Foot 41 | 2:3 | ||||
| 8. Round | 25/09/2021 | Blois Foot 41 | - | AS Poissy | 1:1 | ||||
| 10. Round | 23/10/2021 | Blois Foot 41 | - | Châteaubriant Voltigeurs | 1:1 | ||||
| 12. Round | 20/11/2021 | Blois Foot 41 | - | US Granvillaise | 2:2 | ||||
| 16. Round | 22/01/2022 | Blois Foot 41 | - | US Saint-Malo | 1:0 | ||||
| 17. Round | 05/02/2022 | Stade Plabennec | - | Blois Foot 41 | 2:2 | ||||
| 25. Round | 16/04/2022 | Blois Foot 41 | - | Vannes OC | 5:2 | ||||
| 26. Round | 23/04/2022 | US Granvillaise | - | Blois Foot 41 | 4:2 | ||||
| 27. Round | 30/04/2022 | Blois Foot 41 | - | SO Romorantin | 2:2 | ||||
| 28. Round | 13/05/2022 | FC Rouen 1899 | - | Blois Foot 41 | 1:0 | ||||
| 29. Round | 21/05/2022 | Blois Foot 41 | - | AS Vitré | 5:4 | ||||
| 30. Round | 28/05/2022 | FC Versailles | - | Blois Foot 41 | 3:1 |
France