| 4. Round | 28/08/2021 | US Saint-Malo | - | EA Guingamp B | 0:2 | ||||
| 7. Round | 18/09/2021 | EA Guingamp B | - | Blois Foot 41 | 2:3 | ||||
| 8. Round | 25/09/2021 | FC Lorient B | - | EA Guingamp B | 3:0 | ||||
| 9. Round | 09/10/2021 | EA Guingamp B | - | SM Caen B | 1:1 | ||||
| 10. Round | 23/10/2021 | EA Guingamp B | - | AS Poissy | 1:1 | ||||
| 11. Round | 06/11/2021 | C'Chartres Football | - | EA Guingamp B | 1:2 | ||||
| 12. Round | 20/11/2021 | EA Guingamp B | - | Châteaubriant Voltigeurs | 2:3 | ||||
| 14. Round | 11/12/2021 | EA Guingamp B | - | US Granvillaise | 1:0 |
France