| 4. Round | 25/09/2021 | Dijon FCO [Women] | - | AS Saint-Étienne [Women] | 0:4 | ||||
| 5. Round | 02/10/2021 | AS Saint-Étienne [Women] | - | Paris FC [Women] | 1:3 | ||||
| 6. Round | 17/10/2021 | Paris Saint-Germain [Women] | - | AS Saint-Étienne [Women] | 2:0 | ||||
| 9. Round | 20/11/2021 | ASJ Soyaux [Women] | - | AS Saint-Étienne [Women] | 2:1 | ||||
| 10. Round | 04/12/2021 | EA Guingamp [Women] | - | AS Saint-Étienne [Women] | 1:1 | ||||
| 11. Round | 12/12/2021 | AS Saint-Étienne [Women] | - | Stade de Reims [Women] | 0:1 |  |
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| 12. Round | 15/01/2022 | Montpellier HSC [Women] | - | AS Saint-Étienne [Women] | 3:0 | ||||
| 13. Round | 23/01/2022 | AS Saint-Étienne [Women] | - | Paris Saint-Germain [Women] | 0:5 | ||||
| 19. Round | 16/04/2022 | AS Saint-Étienne [Women] | - | EA Guingamp [Women] | 1:3 | ||||
| 18. Round | 23/04/2022 | AS Saint-Étienne [Women] | - | Dijon FCO [Women] | 2:2 | ||||
| 20. Round | 07/05/2022 | Stade de Reims [Women] | - | AS Saint-Étienne [Women] | 1:0 | |
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| 21. Round | 28/05/2022 | FC Fleury 91 [Women] | - | AS Saint-Étienne [Women] | 4:2 | ||||
| 22. Round | 01/06/2022 | AS Saint-Étienne [Women] | - | ASJ Soyaux [Women] | 0:3 |
France