| 17. Round | 05/02/2022 | SM Caen B | - | St-Pryvé St-Hilaire | 1:4 | ||||
| 19. Round | 19/02/2022 | SM Caen B | - | Blois Foot 41 | 3:2 | ||||
| 20. Round | 05/03/2022 | SO Romorantin | - | SM Caen B | 0:1 | ||||
| 21. Round | 12/03/2022 | SM Caen B | - | FC Lorient B | 1:3 | ||||
| 24. Round | 09/04/2022 | AS Vitré | - | SM Caen B | 2:0 | ||||
| 29. Round | 21/05/2022 | Châteaubriant Voltigeurs | - | SM Caen B | 0:0 | ||||
| 30. Round | 28/05/2022 | SM Caen B | - | Stade Plabennec | 2:2 |
France