| 3. Round | 12/09/2021 | Blois Foot 41 [Youth B] | - | Tours FC [Youth B] | 0:1 | ||||
| 4. Round | 19/09/2021 | Tours FC [Youth B] | - | Paris Saint-Germain [Youth B] | 2:2 | ||||
| 7. Round | 10/10/2021 | AS Vitré [Youth B] | - | Tours FC [Youth B] | 3:1 | ||||
| 8. Round | 17/10/2021 | Tours FC [Youth B] | - | FC Rouen 1899 [Youth B] | 1:2 |  |
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| 9. Round | 24/10/2021 | Montrouge FC [Youth B] | - | Tours FC [Youth B] | 1:1 | ||||
| 10. Round | 14/11/2021 | Tours FC [Youth B] | - | Paris FC [Youth B] | 0:4 | ||||
| 13. Round | 05/12/2021 | Tours FC [Youth B] | - | CS Brétigny [Youth B] | 3:4 | |
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| 14. Round | 16/01/2022 | Havre AC [Youth B] | - | Tours FC [Youth B] | 0:2 | ||||
| 15. Round | 23/01/2022 | Tours FC [Youth B] | - | Blois Foot 41 [Youth B] | 2:0 | ||||
| 19. Round | 13/03/2022 | Tours FC [Youth B] | - | AS Vitré [Youth B] | 2:1 | ||||
| 20. Round | 20/03/2022 | FC Rouen 1899 [Youth B] | - | Tours FC [Youth B] | 2:1 | ||||
| 21. Round | 27/03/2022 | Tours FC [Youth B] | - | Montrouge FC [Youth B] | 1:0 | ||||
| 24. Round | 14/04/2022 | Tours FC [Youth B] | - | US Avranches [Youth B] | 2:3 | ||||
| 25. Round | 01/05/2022 | CS Brétigny [Youth B] | - | Tours FC [Youth B] | 4:3 |
France