| 4. Round | 29/08/2021 | RC Strasbourg | - | Stade Brestois 29 | 3:1 | ||||
| 5. Round | 12/09/2021 | Olympique Lyonnais | - | RC Strasbourg | 3:1 | ||||
| 6. Round | 17/09/2021 | RC Strasbourg | - | FC Metz | 3:0 | ||||
| 7. Round | 22/09/2021 | RC Lens | - | RC Strasbourg | 0:1 |  |
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| 8. Round | 25/09/2021 | RC Strasbourg | - | Lille OSC | 1:2 | |
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| 9. Round | 02/10/2021 | Montpellier HSC | - | RC Strasbourg | 1:1 | ||||
| 10. Round | 17/10/2021 | RC Strasbourg | - | AS Saint-Étienne | 5:1 |  |
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| 11. Round | 24/10/2021 | Stade Rennais | - | RC Strasbourg | 1:0 | |
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| 34. Round | 24/04/2022 | Lille OSC | - | RC Strasbourg | 1:0 | ||||
| 35. Round | 29/04/2022 | RC Strasbourg | - | Paris Saint-Germain | 3:3 | ||||
| 36. Round | 07/05/2022 | Stade Brestois 29 | - | RC Strasbourg | 0:1 | ||||
| 37. Round | 14/05/2022 | RC Strasbourg | - | Clermont Foot 63 | 1:0 |
France