| 1. Round | 25/06/2022 | Santos Laguna [] | - | Deportivo Guadalajara [] | 0:1 | ||||
| 2. Round | 02/07/2022 | Club Tijuana [] | - | Santos Laguna [] | 2:0 | ||||
| 3. Round | 09/07/2022 | Santos Laguna [] | - | CF Monterrey [] | 3:5 |  |
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| 4. Round | 16/07/2022 | Atlético San Luis [] | - | Santos Laguna [] | 2:7 | |
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| 5. Round | 23/07/2022 | Santos Laguna [] | - | Mazatlán FC [] | 5:0 | |
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| 7. Round | 06/08/2022 | Atlas Guadalajara [] | - | Santos Laguna [] | 2:2 | ||||
| 8. Round | 13/08/2022 | Santos Laguna [] | - | UANL Tigres [] | 2:2 | ||||
| 10. Round | 28/08/2022 | Deportivo Guadalajara [] | - | Santos Laguna [] | 1:1 | ||||
| 11. Round | 03/09/2022 | Santos Laguna [] | - | Club León [] | 2:0 | |
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| 12. Round | 10/09/2022 | UANL Tigres [] | - | Santos Laguna [] | 0:2 | |
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| 13. Round | 17/09/2022 | Santos Laguna [] | - | Atlas Guadalajara [] | 2:0 | |
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| 9. Round | 21/09/2022 | Club León [] | - | Santos Laguna [] | 4:1 | ||||
| 15. Round | 01/10/2022 | Mazatlán FC [] | - | Santos Laguna [] | 2:3 | |
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| 16. Round | 08/10/2022 | Santos Laguna [] | - | Atlético San Luis [] | 4:0 | |
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| 17. Round | 15/10/2022 | CF Monterrey [] | - | Santos Laguna [] | 1:1 | ||||
| 18. Round | 22/10/2022 | Santos Laguna [] | - | Club Tijuana [] | 1:0 | |
Mexico