| 1. Round | 22/08/2021 | Lille OSC [Youth] | - | Montfermeil FC [Youth] | 1:0 | ||||
| 2. Round | 29/08/2021 | St-Pryvé St-Hilaire [Youth] | - | Lille OSC [Youth] | 1:2 | ||||
| 3. Round | 05/09/2021 | Lille OSC [Youth] | - | Évreux FC 27 [Youth] | 3:2 | ||||
| 4. Round | 11/09/2021 | Lille OSC [Youth] | - | Entente Feignies Aulnoye [Youth] | 3:1 | ||||
| 5. Round | 19/09/2021 | Amiens SC [Youth] | - | Lille OSC [Youth] | 1:2 | ||||
| 6. Round | 26/09/2021 | Lille OSC [Youth] | - | JA Drancy [Youth] | 0:1 | ||||
| 8. Round | 10/10/2021 | Lille OSC [Youth] | - | Havre AC [Youth] | 1:1 | ||||
| 9. Round | 16/10/2021 | SM Caen [Youth] | - | Lille OSC [Youth] | 2:2 | ||||
| 18. Round | 13/02/2022 | JA Drancy [Youth] | - | Lille OSC [Youth] | 4:3 | ||||
| 20. Round | 20/03/2022 | Havre AC [Youth] | - | Lille OSC [Youth] | 4:2 | ||||
| 24. Round | 17/04/2022 | US Orléans [Youth] | - | Lille OSC [Youth] | 4:2 | ||||
| 25. Round | 01/05/2022 | Lille OSC [Youth] | - | RC Lens [Youth] | 2:0 |
France